Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells.
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چکیده
منابع مشابه
Comments on "Nonlinear Relation between Vmax and INa in Canine Cardiac Purkinje cells.
We studied the relation of the maximal upstroke velocity (Vmax) of action potentials to the peak sodium current (INa) under voltage clamp in single, internally perfused, canine cardiac Purkinje cells under conditions that ensured membrane action potentials due only to INa. Three different methods of altering sodium channel availability were investigated: voltage-dependent inactivation, tetrodot...
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An electrophysiological analysis of canine single ventricular myocardial (VM) and Purkinje (P) cells was carried out by means of whole cell voltage clamp method. The following results in VM versus P cells were obtained. INa3 was present, had a threshold negative to the fast activating-inactivating INa1, its slow inactivation was cut off by INa1, and contributed to Na+ influx at INa1 threshold. ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1988
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.63.2.386